1960 was a crucial year for Vedova. The volume Pagine di diario is released, a collection of writings by the artist with a text by Werner Haftmann. At the XXX Venice Biennale, the artist wins the Grand Prize for painting.
He has a personal room where he exhibits eleven paintings from the collections of Giuseppe Panza di Biumo, Paolo Marinotti and Galleria Blu in Milan. The style of the paintings is very similar to Ciclo S.8. The painting is vigorous: the reds, yellows and blues have bright tones.

The vernissage days at the Giardini offered Vedova the chance to catch up with friends among critics and artists. Philip Guston and Dore Ashton were New York acquaintances he met in Venice during those days. Philip Guston is among the artists invited to exhibit in the United States pavilion, where he gathered together thirteen paintings, mostly from museums such as MoMA and the Whitney in New York, and the Albright Art Gallery in Buffalo, and from galleries such as the Sidney Janis Gallery or from private collections such as that of Ileana Castelli.

In the works on paper from this period, the characteristic expressive force of the artist re-emerges, always centered on the range of reds, yellows and blues. In some works, black becomes the background that highlights chromatic weaves with bright tones.